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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Naturearrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Nature
Article . 1966 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
Nature
Article . 1967
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‘Thalidomide’ Syndrome in Baboons

Authors: A G, Hendrickx; L R, Axelrod; L D, Clayborn;

‘Thalidomide’ Syndrome in Baboons

Abstract

NUMEROUS attempts to reproduce the malformations which occurred in human babies from ‘Thalidomide’-treated mothers have met with only limited success1–3. Although many representatives of aves and mammalian experimental species have been investigated for this purpose, the results fall short of paralleling the effect of the drug on the human foetus4. Sub-human primates have been utilized on two occasions5,6. Lucey and Behrmann5 showed that treating rhesus monkeys with ‘Thalidomide’ before implantation resulted in the inhibition of implantation. Delahunt and Lassen6 induced typically malformed foetuses in four of seven pregnant Cynomolgus monkeys which were treated after implantation had already occurred (days 32–42). Although the embryology of the baboon has not been investigated as extensively as that of some other sub-human primates, developmental processes paralleling those in the human have been found7. Further investigation of the embryology is in progress.

Related Organizations
Keywords

Abnormalities, Drug-Induced, Animals, Haplorhini, Thalidomide

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    popularity
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    Average
    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
45
Average
Top 10%
Top 10%
Related to Research communities
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