Testing Chemicals for Mutagenicity in a Mammal

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1966 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 210, pages 205-206 (issn: 0028-0836, eissn: 1476-4687,

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Authors: A J, Bateman;

doi: 10.1038/210205a0

pmid: 5962088

Testing Chemicals for Mutagenicity in a Mammal

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Abstract

WHILE admitting that mammals would be preferable to diptera for testing newly introduced drugs for possible genetic (that is, mutagenic) effects, Prof. Luning1 argues that tests with mice would be expensive and time consuming and therefore advocates the use of Drosophila larvae grown on medium containing the drug, which are then tested for chromosome loss and non-disjunction.

Related Organizations

Christie Hospital NHS Foundation Trust
United Kingdom
The Christie Hospital
United Kingdom
Cancer Research UK Manchester Institute
United Kingdom

Keywords

Male, Mice, Pregnancy, Mutation, Animals, Biological Assay, Female, Fetal Death, Mutagens, Rats

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