Platelet Reaction to Adenosine Diphosphate in vivo
Copyright policy )Platelet Reaction to Adenosine Diphosphate in vivo
ADENOSINE diphosphate (ADP) causes agglutination of human1–3, cat4 and rabbit3,5 platelets in vitro and has also been shown to produce a rapid though transient fall in the number of circulating platelets when injected intravascularly4–6. Born and Cross4 postulated that the intravenous injection of the nucleotide led to a drop in the platelet count because “platelets adhere to endothelium and form aggregates which are trapped in the smallest vessels”. To test the hypothesis we observed platelet behaviour in small vessels following intravascular injection of ADP.
- Australian National University Australia
Adenosine Diphosphate, Blood Platelets, Pharmacology, Adenine Nucleotides, Physiology, Research, Leukocytes, Thrombosis, Leukopenia, Rabbits
Adenosine Diphosphate, Blood Platelets, Pharmacology, Adenine Nucleotides, Physiology, Research, Leukocytes, Thrombosis, Leukopenia, Rabbits
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