Erythrocyte Osmotic Fragility in AKR Mice with Lymphoid Leukæmia

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1963 United States English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 198, pages 1,103-1,104 (issn: 0028-0836, eissn: 1476-4687,

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Authors: Wiadrowski, M; Metcalf, D;

doi: 10.1038/1981103b0

pmid: 14000448

Erythrocyte Osmotic Fragility in AKR Mice with Lymphoid Leukæmia

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Abstract

INVESTIGATIONS to characterize the anaemia occurring in mouse lymphoid leukaemia have recently involved a comparison of the erythrocyte osmotic fragility in mice of the low-leukaemia strain C5H, and the high-leukaemia strain AKR, using the technique of Creed1. Mice were bled under ether anaesthesia by cutting the axillary blood vessels and gently aspirating the blood with a wide-bore Pasteur pipette. The blood was immediately transferred to a heparinized test-tube, and the osmotic fragility of the cells tested within 5 min of collection of the blood.

Country

United States

Related Organizations

Royal Melbourne Hospital
Australia
Melbourne Health
Australia
Jackson Laboratory
United States
Walter and Eliza Hall Institute of Medical Research
Australia

Keywords

Erythrocytes, Leukemia, Anemia, C3H, Organs:, Leukemia, Lymphoid, Mice, Mice, Inbred AKR, Osmotic Fragility, Types of Tumors:, Strains: AKR, Animals, Pathology:, Hereditary Factors:, Neoplasm:

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