Determination of Argininosuccinic Acid by Ion-Exchange Chromatography

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1961 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 192, pages 555-556 (issn: 0028-0836, eissn: 1476-4687,

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Authors: D C, CUSWORTH; R G, WESTALL;

doi: 10.1038/192555a0

pmid: 13882794

Determination of Argininosuccinic Acid by Ion-Exchange Chromatography

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Abstract

RECENTLY, an unknown amino-acid excreted in the urine by two mentally defective children1 was identified as argininosuccinic acid (ASA)2. This is unstable in weakly acid aqueous solutions and cyclizes3. More recently Westall4 has shown that under these conditions two separate types of anhydride (B and C) are formed, rapidly at high but more slowly at room temperatures.

Related Organizations

University of London
United Kingdom
University College Hospital
United Kingdom

Keywords

Succinates, Arginine, Chromatography, Ion Exchange, Argininosuccinic Acid

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