Hæmolytic Activity of Colloidal Silica

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1961 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 189, pages 1,010-1,011 (issn: 0028-0836, eissn: 1476-4687,

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Authors: J D, HARLEY; J, MARGOLIS;

doi: 10.1038/1891010a0

pmid: 13711605

Hæmolytic Activity of Colloidal Silica

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Abstract

COLLOIDAL silica is highly toxic when administered parenterally1,2. In isolated biological systems silica has been shown to interfere with some enzymes3,4, activate blood clotting and pharmacologically active substances in plasma5 and interfere with the red cell envelope6. Most of these effects are probably due to the adsorption and partial denaturation of proteins at the surface of silica particles5,7.

Related Organizations

Children's Hospital at Westmead
Australia
Alexandra Hospital
Singapore
Medical Research Foundation
United Kingdom

Keywords

Cell Death, Silicon Dioxide, Hemolysis

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