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Drug-induced Immunological Tolerance

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1959Publisher:Springer Science and Business Media LLCJournal:Nature, volume 183, pages 1,682-1,683 (issn: 0028-0836, eissn: 1476-4687,

Authors: William Dameshek; Robert S. Schwartz;

doi: 10.1038/1831682a0

pmid: 13666859

Drug-induced Immunological Tolerance

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Abstract

PREVIOUS work in this laboratory demonstrated that administration of a purine analogue, 6-mercaptopurine, suppressed the antibody response to a soluble antigen (human serum albumin) in rabbits1. It was shown that the antimetabolite could block completely the primary immune response to the purified protein antigen; its effect on the secondary response, however, was minimal2. It is the purpose of this communication to describe the apparent induction of immunological tolerance in adult rabbits by the use of 6-mercaptopurine.

Keywords

Mercaptopurine, Immune Tolerance, Immunity, Humans, Adaptive Immunity

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	528
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 0.1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%