Structure of Kainic Acid and its Isomer, Allokainic Acid

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1958 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 181, pages 761-762 (issn: 0028-0836, eissn: 1476-4687,

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Authors: I, NITTA; H, WATASE; Y, TOMIIE;

doi: 10.1038/181761b0

pmid: 13517293

Structure of Kainic Acid and its Isomer, Allokainic Acid

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Abstract

IN 1953, Murakami, Takemoto and their collaborators1 isolated the most active component of Digenea simplex Agardh which has been well known as an anthelmintic (vermifuge) for more than a thousand years. They named it kainic acid after ‘Kaininso’, the Japanese name of the mother alga. Kainic acid, C10H15O4N, has an intense anthelmintic effect, about ten times that of santonin, without side-effects. In conjunction with chemical studies2 to determine the structure of this interesting compound, we have carried out a structural determination by means of X-ray crystal analysis.

Related Organizations

Osaka University
Japan

Keywords

Kainic Acid, Isomerism, Proline

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