
doi: 10.1038/180805a0
THE determination of the degree of polymerization of polyamides or polypeptides by end-group titration is, in effect, a determination of the amount of the weakly acidic carboxyl group (dissociation constant K 2) in presence of a large excess of the base of a stronger acid, the amide or peptide group (dissociation constant K 1).
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