LUKENS1 depancreatized young pigs, and found that the diabetic state which followed was characterized by a slight or absent fasting glucose-excretion, and a low fasting nitrogen-excretion. Ketonuria was marked, but was not accompanied by severe acidosis. These observations are in contrast with those on the depancreatized cat or dog, and the question arises whether a pure beta-cell deficiency diabetes induced by alloxan in the pig is also different from the corresponding condition in other animals. No account of this form of experimental diabetes in the pig has been found in the literature, and this is a preliminary report on the effects of alloxan on the young pig.