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Nature
Article . 1950 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
Nature
Article . 2004
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Salicylhydroxamic Acid as an Antitubercular Agent

Authors: T, URBANSKI;

Salicylhydroxamic Acid as an Antitubercular Agent

Abstract

SOME derivatives of salicylic acid possess antitubercular properties, the most important of such substances being the well-known p-aminosalicylic acid used by Lehmann1. Nevertheless, numerous investigations seem to indicate that most of the antitubercular compounds contain amino-groups. Hydroxamic acids can be used as reagents to introduce primary amino-groups into an aromatic nucleus, as found by Turski2. I have recently confirmed this3 by using diacetyl-aceto-hydroxamic acid (O N N-triacetylhydroxylamine) as an aminating agent. Upon the assumption that this compound would combine the curative properties of some salicylic acid derivatives with those of amino-compounds, the hydroxamic acid group being in a way a potential amino-group, it seemed worth while to test the value of salicylhydroxamic acid as an antitubercular agent.

Keywords

Salicylamides, Antitubercular Agents, Tuberculosis, Salicylates

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
43
Average
Top 1%
Average
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