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Nature
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Nature
Article . 1950 . Peer-reviewed
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Nature
Article . 2004
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Antibacterial and Antifungal Activity of Benztropolone

Authors: A J, BAILLIE; G G, FREEMAN; J W, COOK; A R, SOMERVILLE;

Antibacterial and Antifungal Activity of Benztropolone

Abstract

FOLLOWING the suggestion of Dewar1, it is now generally accepted that the mould metabolic products, stipitatic acid, puberulic acid and puberulonic acid are derivatives of tropolone2. Erdtman and Gripenberg3 have shown that α-, β- and γ-thujaplicins from Thuja plicata, the western red cedar tree, are, respectively, α-, β- and γ-isopropyltropolones. γ-Thujaplicin was found to possess fungicidal activity; when spores of Pullularia pullulans were suspended in a 0.02 per cent solution, 100 per cent survived after 1 hr., 11 per cent after 3 hr. and none after 6 hr. and 24 hr. exposure. Two of us (J. W. C. and A. R. S.) have recently described a synthesis of 3 : 4-benztropolone4.

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Keywords

Antifungal Agents, Tropolone, Anti-Bacterial Agents, Fungicides, Industrial

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    popularity
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
11
Average
Top 10%
Average
bronze
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