Release of Histamine by Ammonia

descriptionPublicationkeyboard_double_arrow_right Article 02 Jul 1949 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 164, pages 24-25 (issn: 0028-0836, eissn: 1476-4687,

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Authors: H O, SCHILD;

doi: 10.1038/164024b0

pmid: 18145914

Release of Histamine by Ammonia

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Abstract

HISTAMINE is released from tissues in anaphylaxis, by trypsin, peptones, snake poisons, curare and diamidines. Garan1 has shown that ammonia vapour liberates histamine from guinea pigs' lungs. The following experiments show that histamine is quantitatively released from striated muscle in a solution of ammonium chloride, but that the effect is entirely dependent on pH, suggesting that it is produced by the free base.

Related Organizations

University College London
United Kingdom

Keywords

Ammonia, Histamine

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