Adsorption of Bacterial Polysaccharides to Erythrocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1948 English Publisher:Springer Science and Business Media LLCJournal:Nature, volume 161, pages 687-688 (issn: 0028-0836, eissn: 1476-4687,

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Authors: E V, KEOGH; E A, NORTH; M F, WARBURTON;

doi: 10.1038/161687b0

pmid: 18938457

Adsorption of Bacterial Polysaccharides to Erythrocytes

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Abstract

WE recently reported that saline extracts of smooth strains of Haemophilus influenzae (Type b) contain a substance adsorbable to erythrocytes1. Cells treated with such extracts are agglutinated by type-specific antisera. A sample of the type-specific polysaccharide, prepared by the method of Dingle and Fothergill2, absorbed from immune sera their power of agglutinating erythrocytes so sensitized, but was not itself capable of sensitizing them. We concluded, therefore, that the fraction in saline extracts which was adsorbed to erythrocytes was a combination of the type-specific polysaccharide with some other substance.

Keywords

Erythrocytes, Polysaccharides, Bacterial, Adsorption

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