Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Naturearrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Nature
Article . 1947 . Peer-reviewed
License: Springer Nature TDM
Data sources: Crossref
Nature
Article . 2010
versions View all 2 versions
addClaim

Misuse of âDeduced Ratiosâ in the Estimation of Median Effective Doses

Authors: C V, WINDER;

Misuse of âDeduced Ratiosâ in the Estimation of Median Effective Doses

Abstract

Dragstedt and Lang1 wrote: “It seems to us obvious that a rabbit that died from 100 mgm. would have died of any higher dose and one that survived from 150 mgm. per kilogram would have survived from any lesser dose”, and tabulated their “mortality percentages” as deduced according to “this rationale” from experienced ratios at the various doses. Behrens2, with a similar idea, pointed out its limitations: “Unter der Voraussetzung, dass es sich um ein stetiges Kollektiv handelt, dass in den einzelnen Gruppen gleichviel Tiere angesetzt werden [or percentages in place of experienced effect ratios be used] und dass, die Gruppenabstande nach beiden Seiten [of the expected median dose] gleichgross sind (arithmetische Reihe [elsewhere he correctly advocates a geometric progression]), ist zu erwarten, dass die Gesamptzahl der bei niederen Dosen Gestorbenen gleich ist derjenigen der Uberlebenden bei hoheren Dosen vom erwarteten Wert aus betrachtet. Selbstverstandlich mussen wir die gesamte Ausdehnung unseres Kollektives mit den Gruppen erfassen”. Behrens pointed out that the deduced ratio at a given dose is not the mortality ratio except at the value 1/2 ; that the ratios deal with areas on, rather than with ordinates of, the cumulative frequency curve.

Related Organizations
Keywords

Dosage Forms, Humans, Regression Analysis

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    1
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!