
doi: 10.1038/153745a0
THE presence of p-cresol in human urine, as well as in the urine of horses, cows and other animals, has been known for a long time. It occurs mainly as a salt of p-tolylsulphuric acid. According to Siegfried and Zimmermann1, the average concentration of p-cresol in normal human urine is of the order of 18 mgm. per litre, and in a man with an, adrenal tumour a value of 25 mgm. per litre has been reported2. In the urine of pregnant mares, Marshall has found that the concentration is 60 mgm. per litre3.
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