AbstractThe global COVID‐19 outbreak severely hampered the growth of the global economy, prompting the implementation of the strictest prevention policies in China. Establishing a significant relationship between changes in nighttime light and COVID‐19 lockdowns from a geospatial perspective is essential. In light of nighttime light remote sensing, we evaluated the spatiotemporal dynamic effects of COVID‐19 city lockdowns on human activity intensity in the Zhengzhou region. Prior to the COVID‐19 outbreak, nighttime light in the Zhengzhou region maintained a significant growth trend, even under regular control measures. However, following the October 2022 COVID‐19 lockdown, nighttime light experienced a substantial decrease. In the central area of Zhengzhou, nighttime light decreased by at least 18% compared to pre‐lockdown levels, while in the sub‐center, the decrease was around 14%. The areas where nighttime light decreased the most in the central region were primarily within a 15 km radius, while in the sub‐center, the decrease was concentrated within a 5 km radius. These changes in both statistical data and nighttime light underscored the significant impact of the COVID‐19 lockdown on economic activities in the Zhengzhou region.