AbstractThe Origins, Spectral Interpretation, Resource Identification, and Security‐Regolith Explorer (OSIRIS‐REx) mission observed the Moon during the spacecraft's Earth gravity assist in 2017. From the spacecraft view, the lunar phase was 42°, and the in‐view hemisphere was dominated by anorthositic highlands terrain. Lunar spectra obtained by the OSIRIS‐REx Visible and InfraRed Spectrometer show evidence of several candidate absorption features. We observe the 2.8‐μm hydration band, confirming the spectral results from other missions, but detected in full‐disk spectra. We also tentatively identify weak spectral features near 0.9 and 1.3 μm, consistent with lunar regolith containing a mixture of plagioclase and orthopyroxene minerals, as expected for highlands terrain.