Synthesis and Antitumor Activity of Tanshinone Analogues

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2003 China (People's Republic of) English Publisher:Springer Science and Business Media LLCJournal:Chemistry of Natural Compounds, volume 39, pages 404-406 (issn: 0009-3130, eissn: 1573-8388,

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Authors: Aisa, HA; Lu, W; Cai, JC;

doi: 10.1023/b:conc.0000003428.26731.7f , 10.1002/cjoc.20030210703

handle: 10722/168004 , 10722/168035 , 10722/168079

Synthesis and Antitumor Activity of Tanshinone Analogues

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Abstract

Abstract8,8‐Dimethyl‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (3) and 8,8‐dimethyl‐2‐(l‐hydroxy ethyl)‐5,6,7,8‐tetrahydrophenanthrene‐3,4‐dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P‐388 cell line as assayed by in vitro MTT method.

Country

China (People's Republic of)

Related Organizations

Chinese Academy of Sciences
China (People's Republic of)
Xinjiang Technical Institute of Physics & Chemistry
China (People's Republic of)
University of Hong Kong
China (People's Republic of)
University of Hong Kong (香港大學)
China (People's Republic of)
Shanghai Institute of Materia Medica
China (People's Republic of)

Keywords

Synthesis, Analogues, Tanshinone

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