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Allosteric Drugs Acting at Muscarinic Acetylcholine Receptors

Name: Allosteric Drugs Acting at Muscarinic Acetylcholine Receptors
Creator: Waelbroeck, Magali
Keywords: 0301 basic medicine, 0303 health sciences, Muscarinic -- metabolism, Sciences bio-médicales et agricoles, Biological, Ligands, Models, Biological, Receptors, Muscarinic, 3. Good health, 03 medical and health sciences

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2003 Belgium English Publisher:Springer Science and Business Media LLCJournal:Neurochemical Research, volume 28, pages 419-422 (issn: 0364-3190, eissn: 1573-6903,

Authors: Waelbroeck, Magali;

doi: 10.1023/a:1022888332221

pmid: 12675125

handle: 2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/57521

Allosteric Drugs Acting at Muscarinic Acetylcholine Receptors

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Abstract

The binding properties of muscarinic acetylcholine receptors are affected by various drugs acting at a second (allosteric) binding site, usually (but not always) at supratherapeutic concentrations. Allosteric drugs acting at GABA receptors present advantages over competitive drugs; this explains the interest raised by allosteric effects on muscarinic receptors. A theoretical and practicable definition of allosteric drugs acting at muscarinic receptors will be given in this work, together with a summary of recent data concerning the number, position, and structural requirements of their binding sites.

Country

Belgium

Related Organizations

Université Libre de Bruxelles
Belgium

Keywords

Muscarinic -- metabolism, Sciences bio-médicales et agricoles, Biological, Ligands, Models, Biological, Receptors, Muscarinic, Allosteric Regulation, Models, Receptors, Animals

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