descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2000 English Publisher:Springer Science and Business Media LLCJournal:Transgenic Research, volume 9, pages 263-275 (issn: 0962-8819, eissn: 1573-9368,

Authors: Sarah Burl; Chris Denning; Paul Dickinson; Anthony John Clark;

doi: 10.1023/a:1008974616402

pmid: 11131006

Gene targeting in livestock: a preview

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Abstract

Until recently genetically modified livestock could only be generated by pronuclear injection. The discovery that animals can be cloned by nuclear transfer from cultured somatic cells means that it will now be possible to achieve gene targeting in these species. We discuss current developments in NT, the prospects and technical challenges for introducing targeted changes into the germline by this route, and the types of application for which this new technology will be used.

Related Organizations

University of Edinburgh
United Kingdom
Biotechnology and Biological Sciences Research Council
United Kingdom
Roslin Institute
United Kingdom

Keywords

Nuclear Transfer Techniques, Animals, Domestic, Cloning, Organism, Gene Targeting, Animals

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