Identification, expression and tissue distribution of cytidine 5′-monophosphate N-acetylneuraminic acid synthetase activity in the rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1998 English Publisher:Springer Science and Business Media LLCJournal:Glycoconjugate Journal, volume 15, pages 233-241 (issn: 0282-0080, eissn: 1573-4986,

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Authors: B, Revilla-Nuin; A, Reglero; J C, Feo; L B, Rodriguez-Aparicio; M A, Ferrero;

doi: 10.1023/a:1006940927639

pmid: 9579800

Identification, expression and tissue distribution of cytidine 5′-monophosphate N-acetylneuraminic acid synthetase activity in the rat

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Abstract

We report the postnatal developmental profiles of N-acetylneuraminic acid cytidylyltransferase (EC 2.7.7.43) (CMP-Neu5Ac synthetase) in different rat tissues. This enzyme, which catalyses the activation of NeuAc to CMP-Neu5Ac, was detected in brain, kidney, heart, spleen, liver, stomach, intestine, lung, thymus, prostate and urinary bladder but not in skeletal muscle. Comparative analysis of the different specific activity profiles obtained shows that the expression of CMP Neu5Ac synthetase is tissue-dependent and does not seem to be embryologically determined. Changes in the level of sialylation during development were also found to be intimately related to variations in the expression of this enzyme, at least in brain, heart, kidney, stomach, intestine and lung.

Related Organizations

University of Leon
Spain

Keywords

Male, N-Acylneuraminate Cytidylyltransferase, Ovary, Brain, Kidney, Muscle Development, Rats, Animals, Newborn, Liver, Testis, Animals, Female, Tissue Distribution, Rats, Wistar, Muscle, Skeletal, Digestive System, Lung, Spleen

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