OBOC Small-Molecule Combinatorial Library Encoded by Halogenated Mass-Tags

descriptionPublicationkeyboard_double_arrow_right Article 17 Sep 2004 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 6, pages 3,829-3,832 (issn: 1523-7060, eissn: 1523-7052,

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Authors: Sung Hee, Hwang; Alan, Lehman; Xin, Cong; Marilyn M, Olmstead; Kit S, Lam; Carlito B, Lebrilla; Mark J, Kurth;

doi: 10.1021/ol048408e

pmid: 15469360

OBOC Small-Molecule Combinatorial Library Encoded by Halogenated Mass-Tags

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Abstract

[reaction: see text] A bromine-/chlorine-containing mass-tag encoding strategy for a small-molecule OBOC combinatorial library is reported. The resulting MALDI FTMS isotope pattern of each tag clearly defines the component building blocks of each "hit" bead in an 1890-member demonstration library screened on-bead for binding against streptavidin via both enzyme-linked colorimetric and Quantum Dot/COPAS assays.

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