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Organic Letters
Article
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Organic Letters
Article . 2003 . Peer-reviewed
Data sources: Crossref
Organic Letters
Article . 2003 . Peer-reviewed
Data sources: Crossref
Organic Letters
Article . 2004
Data sources: Europe PubMed Central
https://dx.doi.org/10.1021/ol0...
Article
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Solid-Phase Synthesis of Disulfide Heterodimers of Peptides

descriptionPublicationkeyboard_double_arrow_right Article 26 Aug 2003 English Publisher:American Chemical Society (ACS)Journal:Organic Letters, volume 5, pages 4,525-4,525 (issn: 1523-7060, eissn: 1523-7052, Copyright policy )
Authors: Amit K, Galande; Arno F, Spatola;

doi: 10.1021/ol035903m , 10.1021/ol0300827

pmid: 12967292

Solid-Phase Synthesis of Disulfide Heterodimers of Peptides

Abstract

[structure: see text] The synthesis of the orthogonal disulfide template 1 and its use to synthesize unsymmetrical intermolecular disulfide bond peptides on a solid support are described. Application of template 1 to synthesize bioconjugates of cell permeable moieties based on the disulfide bond is demonstrated.

Related Organizations
Keywords

Molecular Structure, Drug Design, Amino Acid Sequence, Cysteine, Disulfides, Peptides, Dimerization, Peptides, Cyclic

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    		 19
    popularity
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    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Average
Top 10%
Top 10%
bronze