Cytotoxic Oxygenated Desmosterols of the Red Alga Galaxaura marginata
Copyright policy )Cytotoxic Oxygenated Desmosterols of the Red Alga Galaxaura marginata
Desmosterol (1), 24,25-epoxycholesterol (2), 24-hydroperoxycholesta-5,25-dien-3 beta-ol (3), 25-hydroperoxycholesta-5,23(E)-dien-3 beta-ol (4), cholesta-5,25-diene-3 beta,24-diol (5), and 24,25-epoxy-6 beta-hydroxycholest-4-en-3-one (7) were isolated from the marine red alga Galaxaura marginata; sterols 3, 4, and 7 were isolated for the first time from a natural source. Sterols 3-7 exhibited significant cytotoxicity toward several cancer cell lines.
Mice, Magnetic Resonance Spectroscopy, Desmosterol, Rhodophyta, Tumor Cells, Cultured, Animals, Humans, Antineoplastic Agents, Drug Screening Assays, Antitumor
Mice, Magnetic Resonance Spectroscopy, Desmosterol, Rhodophyta, Tumor Cells, Cultured, Animals, Humans, Antineoplastic Agents, Drug Screening Assays, Antitumor
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