Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats
Copyright policy )Antihyperglycemic Effect of Catalpol in Streptozotocin-Induced Diabetic Rats
The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 0.1 mg/kg 1 significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. Catalpol enhanced the uptake of radioactive glucose in the isolated soleus muscle of STZ-diabetic rats in a concentration-related manner. Moreover, an effect by 1 was established on glycogen incorporation in hepatocytes isolated from STZ-diabetic rats. Catalpol was found to increase glycogen synthesis in STZ-diabetic rats. These results suggest that 1 can increase glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
- National Cheng Kung University Taiwan
- Taipei Medical University Taiwan
Blood Glucose, Male, Plants, Medicinal, Molecular Structure, Iridoid Glucosides, Taiwan, Plant Roots, Diabetes Mellitus, Experimental, Rats, Rehmannia, Glucosides, Hepatocytes, Animals, Hypoglycemic Agents, Insulin, Iridoids, Rats, Wistar, Muscle, Skeletal, Glycogen
Blood Glucose, Male, Plants, Medicinal, Molecular Structure, Iridoid Glucosides, Taiwan, Plant Roots, Diabetes Mellitus, Experimental, Rats, Rehmannia, Glucosides, Hepatocytes, Animals, Hypoglycemic Agents, Insulin, Iridoids, Rats, Wistar, Muscle, Skeletal, Glycogen
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).68 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!