Antiprotealide Is a Natural Product
Copyright policy )Antiprotealide Is a Natural Product
Large-scale fermentation of the marine actinomycete Salinispora tropica for production of salinosporamide A (NPI-0052; 1) clinical trials materials provided crude extracts containing minor secondary metabolites, including salinosporamide B (2) and a new congener, 3. Spectroscopic characterization revealed that 3 is identical to antiprotealide, a molecular hybrid of 20S proteasome inhibitors 1 and omuralide (4) not previously described as a natural product. Analysis of crude extracts from shake flask cultures of three wild-type S. tropica strains confirmed the production of antiprotealide at 1.1, 0.8, and 3.0 mg/L. Thus, antiprotealide is a natural product metabolite of S. tropica.
- Nereus Pharmaceuticals United States
Biological Products, Proteasome Endopeptidase Complex, Lactams, Molecular Structure, Marine Biology, Actinobacteria, Inhibitory Concentration 50, Lactones, Animals, Humans, Pyrroles, Rabbits, Drug Screening Assays, Antitumor
Biological Products, Proteasome Endopeptidase Complex, Lactams, Molecular Structure, Marine Biology, Actinobacteria, Inhibitory Concentration 50, Lactones, Animals, Humans, Pyrroles, Rabbits, Drug Screening Assays, Antitumor
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