Frajunolides E−K, Briarane Diterpenes from Junceella fragilis
Copyright policy )Frajunolides E−K, Briarane Diterpenes from Junceella fragilis
Chemical investigation of the gorgonian octocoral Junceella fragilis, collected in Taiwan, resulted in the isolation of seven new briarane-type diterpenes, frajunolides E-K (1-7), in addition to 14 known briaranes, praelolide, junceellin, junceellolides A-E, and K, 11a,20a-epoxy-4-deacetoxyjunceelolide D, umbraculolide A, junceellonoid A, and juncins Y, Z, and ZI, as well as ergosterol peroxide. The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated.
Molecular Structure, Pancreatic Elastase, Neutrophils, Anti-Inflammatory Agents, Non-Steroidal, Taiwan, Antineoplastic Agents, Anthozoa, Genistein, Animals, Humans, Diterpenes, Drug Screening Assays, Antitumor, Nuclear Magnetic Resonance, Biomolecular
Molecular Structure, Pancreatic Elastase, Neutrophils, Anti-Inflammatory Agents, Non-Steroidal, Taiwan, Antineoplastic Agents, Anthozoa, Genistein, Animals, Humans, Diterpenes, Drug Screening Assays, Antitumor, Nuclear Magnetic Resonance, Biomolecular
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