Antiophidic Solanidane Steroidal Alkaloids from Solanum campaniforme
Copyright policy )Antiophidic Solanidane Steroidal Alkaloids from Solanum campaniforme
Three new solanidane alkaloids bearing a 22,23-epoxy ring (1-3) and four known compounds were isolated from leaves of Solanum campaniforme. The structures were determined using spectroscopic techniques, including 1D and 2D NMR, and HRESIMS experiments. The antiophidic activity of the alkaloids was tested against Bothrops pauloensis venom. Compounds 1-3 completely inhibited myotoxicity without inhibiting phospholipase A2 activity of the venom, while hemorrhage and skin necrosis were significantly reduced in the presence of alkaloids 1 and 2.
- Sao Paulo State University Brazil
- State University of Campinas Brazil
- State University of Ceará Brazil
- Universidade Federal do Ceará Brazil
- Universidade Estadual Paulista - UNESP Brazil
Molecular Structure, Solanum, Plant Leaves, Alkaloids, Crotalid Venoms, Animals, Bothrops, Steroids, Nuclear Magnetic Resonance, Biomolecular, Brazil
Molecular Structure, Solanum, Plant Leaves, Alkaloids, Crotalid Venoms, Animals, Bothrops, Steroids, Nuclear Magnetic Resonance, Biomolecular, Brazil
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