descriptionPublicationkeyboard_double_arrow_right Article 12 Jul 2005 English Publisher:American Chemical Society (ACS)Journal:Journal of Natural Products, volume 68, pages 1,274-1,276 (issn: 0163-3864, eissn: 1520-6025,

Authors: Samir A. Ross; Mahmoud A. ElSohly; Ahmed M. Galal; Melissa R. Jacob;

doi: 10.1021/np050074u

pmid: 16124777

Antifungal Activity of Artemisinin Derivatives

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Abstract

A series of 29 artemisinin derivatives (2-30), including four new compounds (16-18, 20), together with artemisinin (1), artemisinic acid (31), and arteannuin B (32), were tested for antifungal activity against two opportunistic pathogens, Candida albicans and Cryptoccocus neoformans. Of all the compounds tested, anhydrodihydro-artemisinin (3) demonstrated more potent antifungal activity against C. neoformans than amphotericin B. Also, beta-arteether (7) and alpha-arteether (8) showed marked activity against C. neoformans. Against C. albicans, the overall antifungal effect of these compounds was weak or negligible. Derivatives 2-30 were prepared according to literature procedures.

Related Organizations

University of Mississippi
United States
Cairo University
Egypt
Mississippi Institutions of Higher Learning
United States

Keywords

Antifungal Agents, Molecular Structure, Candida albicans, Cryptococcus neoformans, Combinatorial Chemistry Techniques, Microbial Sensitivity Tests, Artemisinins

1 Research products, page 1 of 1

An HPLC‐MS method for simultaneous estimation of α,β‐arteether and its metabolite dihydroartemisinin, in rat plasma for application to pharmacokinetic study
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