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Oxidation of Tyrosine Diketopiperazine to DOPA Diketopiperazine with Tyrosine Hydroxylase

descriptionPublicationkeyboard_double_arrow_right Article 07 Jul 2004 English Publisher:American Chemical Society (ACS)Journal:Journal of Natural Products, volume 67, pages 1,390-1,391 (issn: 0163-3864, eissn: 1520-6025, Copyright policy )
Authors: Maysoon B, Saleh; Russell G, Kerr;

doi: 10.1021/np034083j

pmid: 15332860

Oxidation of Tyrosine Diketopiperazine to DOPA Diketopiperazine with Tyrosine Hydroxylase

Abstract

The diketopiperazine of DOPA was synthesized in high yield from the diketopiperazine of tyrosine using PC12 cell lysate, which expresses high levels of tyrosine hydroxylase. This represents the first use of this enzyme to prepare DOPA-containing peptides.

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Keywords

Molecular Structure, Tyrosine 3-Monooxygenase, Animals, Tyrosine, Diketopiperazines, Peptides, Oxidation-Reduction, PC12 Cells, Piperazines, Dihydroxyphenylalanine, Rats

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Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Average
Average
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