Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles
Copyright policy )Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles
Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells. These nanoparticles allow precise control over their formulation, stability in blood serum, and activation of multiple functionalities. Importantly, interferon and pro-inflammatory cytokine activation assays indicate the significantly lower responses for DNA nanoparticles compared to the RNA counterparts, suggesting greater potential of these molecules for therapeutic use.
- National Institute of Health Pakistan
- National Cancer Institute United States
- Leidos Biomedical Research Inc. (United States) United States
- Center for Cancer Research United States
- Frederick National Laboratory for Cancer Research United States
Models, Molecular, Ribonuclease III, Drug Carriers, DNA, HEK293 Cells, HIV-1, Humans, Nanoparticles, Nucleic Acid Conformation, RNA, RNA Interference, RNA, Small Interfering
Models, Molecular, Ribonuclease III, Drug Carriers, DNA, HEK293 Cells, HIV-1, Humans, Nanoparticles, Nucleic Acid Conformation, RNA, RNA Interference, RNA, Small Interfering
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