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Nano Letters
Article
License: CC BY
Data sources: UnpayWall
Nano Letters
Article . 2008 . Peer-reviewed
Data sources: Crossref
Nano Letters
Article . 2008
Data sources: Europe PubMed Central
https://dx.doi.org/10.1021/nl0...
Article
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Mesoporous Silica Nanoparticles Inhibit Cellular Respiration

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2008 English Publisher:American Chemical Society (ACS)Journal:Nano Letters, volume 8, pages 1,517-1,526 (issn: 1530-6984, eissn: 1530-6992, Copyright policy )
Authors: Zhimin, Tao; Matthew P, Morrow; Tewodros, Asefa; Krishna K, Sharma; Cole, Duncan; Abhishek, Anan; Harvey S, Penefsky; +2 Authors

doi: 10.1021/nl080250u

pmid: 18376867

Mesoporous Silica Nanoparticles Inhibit Cellular Respiration

Abstract

We studied the effect of two types of mesoporous silica nanoparticles, MCM-41 and SBA-15, on mitochondrial O 2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) cells, and isolated mitochondria. SBA-15 inhibited cellular respiration at 25-500 microg/mL; the inhibition was concentration-dependent and time-dependent. The cellular ATP profile paralleled that of respiration. MCM-41 had no noticeable effect on respiration rate. In cells depleted of metabolic fuels, 50 microg/mL SBA-15 delayed the onset of glucose-supported respiration by 12 min and 200 microg/mL SBA-15 by 34 min; MCM-41 also delayed the onset of glucose-supported respiration. Neither SBA-15 nor MCM-41 affected cellular glutathione. Both nanoparticles inhibited respiration of isolated mitochondria and submitochondrial particles.

Related Organizations
Keywords

Cell Survival, Cell Respiration, Materials Testing, Humans, Nanoparticles, Particle Size, Silicon Dioxide, Porosity, Cell Line

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
108
Top 10%
Top 10%
Top 1%
hybrid