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Nano Letters
Article
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Nano Letters
Article . 2005 . Peer-reviewed
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https://dx.doi.org/10.48550/ar...
Article . 2004
License: arXiv Non-Exclusive Distribution
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Nano Letters
Article . 2005
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Fast DNA Translocation through a Solid-State Nanopore

Authors: Storm, Arnold J.; Storm, Cornelis; Chen, Jianghua; Zandbergen, Henny; Joanny, Jean-François; Dekker, Cees;

Fast DNA Translocation through a Solid-State Nanopore

Abstract

We report translocation experiments on double-strand DNA through a silicon oxide nanopore. Samples containing DNA fragments with seven different lengths between 2000 to 96000 basepairs have been electrophoretically driven through a 10 nm pore. We find a power-law scaling of the translocation time versus length, with an exponent of 1.26 $\pm$ 0.07. This behavior is qualitatively different from the linear behavior observed in similar experiments performed with protein pores. We address the observed nonlinear scaling in a theoretical model that describes experiments where hydrodynamic drag on the section of the polymer outside the pore is the dominant force counteracting the driving. We show that this is the case in our experiments and derive a power-law scaling with an exponent of 1.18, in excellent agreement with our data.

5 pages, 2 figures. Submitted to PRL

Country
France
Keywords

Microfluidics, Static Electricity, FOS: Physical sciences, Condensed Matter - Soft Condensed Matter, Permeability, Diffusion, Materials Testing, Computer Simulation, Physics - Biological Physics, [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Membranes, Artificial, Biomolecules (q-bio.BM), DNA, Silicon Dioxide, [PHYS.COND.CM-SCM] Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft], Nanostructures, Molecular Weight, Quantitative Biology - Biomolecules, Models, Chemical, Biological Physics (physics.bio-ph), FOS: Biological sciences, Soft Condensed Matter (cond-mat.soft), Stress, Mechanical, Porosity

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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
678
Top 1%
Top 0.1%
Top 0.1%
Green
bronze