Xanthine Dehydrogenase Electrocatalysis: Autocatalysis and Novel Activity
Copyright policy )Xanthine Dehydrogenase Electrocatalysis: Autocatalysis and Novel Activity
The enzyme xanthine dehydrogenase (XDH) from the purple photosynthetic bacterium Rhodobacter capsulatus catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid as part of purine metabolism. The native electron acceptor is NAD(+) but herein we show that uric acid in its 2-electron oxidized form is able to act as an artificial electron acceptor from XDH in an electrochemically driven catalytic system. Hypoxanthine oxidation is also observed with the novel production of uric acid in a series of two consecutive 2-electron oxidation reactions via xanthine. XDH exhibits native activity in terms of its pH optimum and inhibition by allopurinol.
- University of Queensland Australia
- University of Potsdam Germany
- University of Queensland Australia
- University of Queensland Australia
Electrochemical Oxidation, Xanthine Dehydrogenase, Allopurinol, Xanthine, Rhodobacter capsulatus, Coatings and Films, Crystal-Structures, Pyrolytic-Graphite Electrodes, Electrochemistry, Electrodes, 2505 Materials Chemistry, Institut für Biochemie und Biologie, Hypoxanthine, Glassy-Carbon, Hydrogen-Ion Concentration, Uric-Acid Oxidation, NAD, Uric Acid, Rhodobacter-Capsulatus, Biocatalysis, Flavin-Adenine Dinucleotide, 2508 Surfaces, Mechanism, Imines, Cyclic Voltammetry, Oxidase, 1606 Physical and Theoretical Chemistry, Oxidation-Reduction, Gold Electrode
Electrochemical Oxidation, Xanthine Dehydrogenase, Allopurinol, Xanthine, Rhodobacter capsulatus, Coatings and Films, Crystal-Structures, Pyrolytic-Graphite Electrodes, Electrochemistry, Electrodes, 2505 Materials Chemistry, Institut für Biochemie und Biologie, Hypoxanthine, Glassy-Carbon, Hydrogen-Ion Concentration, Uric-Acid Oxidation, NAD, Uric Acid, Rhodobacter-Capsulatus, Biocatalysis, Flavin-Adenine Dinucleotide, 2508 Surfaces, Mechanism, Imines, Cyclic Voltammetry, Oxidase, 1606 Physical and Theoretical Chemistry, Oxidation-Reduction, Gold Electrode
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).16 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!