Synthesis of Cyclic Peptides by Ring-Closing Metathesis

descriptionPublicationkeyboard_double_arrow_right Article 25 Aug 2000 Netherlands English Publisher:American Chemical Society (ACS)Journal:The Journal of Organic Chemistry, volume 65, pages 6,187-6,195 (issn: 0022-3263, eissn: 1520-6904,

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Authors: Reichwein, J.F.; Versluis, C.; Liskamp, R.M.J.;

doi: 10.1021/jo000759t

pmid: 10987958

Synthesis of Cyclic Peptides by Ring-Closing Metathesis

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Abstract

The synthesis of a series of "amide to amide" cyclized peptides by ring-closing metathesis (RCM) as well as a convenient synthesis for the linear precursors is described. In addition, the influence of the length of the alkene substituents and the influence of the peptide sequence is investigated, leading to a set of general rules to obtain "amide to amide" cyclized peptides by RCM.

Country

Netherlands

Related Organizations

Utrecht University
Netherlands

Keywords

Cyclization, Oligopeptides, Peptides, Cyclic, Protein Structure, Secondary

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