Nonsymmetrically Substituted Cyclic Urea HIV Protease Inhibitors

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1997 English Publisher:American Chemical Society (ACS)Journal:Journal of Medicinal Chemistry, volume 40, pages 4,079-4,088 (issn: 0022-2623, eissn: 1520-4804,

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Authors: W W, Wilkerson; S, Dax; W W, Cheatham;

doi: 10.1021/jm970288b

pmid: 9406598

Nonsymmetrically Substituted Cyclic Urea HIV Protease Inhibitors

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Abstract

A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis, pharmacology, quantitative structure-activity relationship (QSAR), and pharmacokinetics for the series will be discussed.

Related Organizations

Wilmington University
United States

Keywords

Structure-Activity Relationship, Anti-HIV Agents, RNA, Viral, Urea, HIV Protease Inhibitors

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