Synthesis and Biological Evaluation of Orally Active Hypolipidemic Agents
Copyright policy )Synthesis and Biological Evaluation of Orally Active Hypolipidemic Agents
A series of novel fenofibric acid ester prodrugs 1c-1h were synthesized and evaluated with the aim of obtaining potent hypolipidemic agents. Prodrugs 1c and 1d exhibited potent hypochlolesterolemic activity, lowering the mice plasma triglyceride level up to 47% in Swiss albino mice after oral administration of 50 mg/kg/day for 8 days. Fenofibric acid ester prodrugs 1c-1h were found lipophilic like fenofibrate (1b), indicated by partition coefficients measured in octanol-buffer system at pH 7.4. On the basis of in vivo studies, prodrugs 1c and 1d emerged as potent hypolipidemic agents.
- Solapur University India
Male, Molecular Structure, Administration, Oral, Esters, Mice, Cholesterol, Fenofibrate, Models, Chemical, X-Ray Diffraction, Animals, Prodrugs, Particle Size, Triglycerides, Hypolipidemic Agents
Male, Molecular Structure, Administration, Oral, Esters, Mice, Cholesterol, Fenofibrate, Models, Chemical, X-Ray Diffraction, Animals, Prodrugs, Particle Size, Triglycerides, Hypolipidemic Agents
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