3-Arylquinolizidines, potential antidepressant agents

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1975 English Publisher:American Chemical Society (ACS)Journal:Journal of Medicinal Chemistry, volume 18, pages 1,126-1,130 (issn: 0022-2623, eissn: 1520-4804,

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Authors: M E, Rogers; J, Sam;

doi: 10.1021/jm00245a016

pmid: 1177258

3-Arylquinolizidines, potential antidepressant agents

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Abstract

The synthesis, structure elucidation, and pharmacological evaluation of some 3-arylquinolizidines as semirigid phenethylamines are described. Many of the derivatives posses antidepressant activity. Some anticonvulsant effects are noted.

Keywords

Serotonin, Molecular Conformation, Stereoisomerism, Motor Activity, Antidepressive Agents, Dihydroxyphenylalanine, Lethal Dose 50, Mice, Acoustic Stimulation, Pargyline, Seizures, Animals, Quinolizines

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