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Journal of Medicinal Chemistry

Article . 1977 . Peer-reviewed

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Journal of Medicinal Chemistry

Article . 1977

Data sources: Europe PubMed Central

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Cephalosporin degradations

Name: Cephalosporin degradations
Creator: A, Dinner
Keywords: Cephalexin, Mice, Inbred ICR, Magnetic Resonance Spectroscopy, Chemical Phenomena, Hydrolysis, 01 natural sciences, Cephalosporins, 3. Good health, 0104 chemical sciences, Chemistry

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1977Publisher:American Chemical Society (ACS)Journal:Journal of Medicinal Chemistry, volume 20, pages 963-965 (issn: 0022-2623, eissn: 1520-4804,

Authors: A, Dinner;

doi: 10.1021/jm00217a022

pmid: 874972

Cephalosporin degradations

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Abstract

The acidic aqueous degradation of the 7alpha-aminophenylglycinamido-containing cephalosporin cephalexin (1a) has been examined. Two major degradation products have been isolated and characterized: 3-formyl-3,6-dihydro-6-phenyl-2.5(1H,4H)-pyrazinedione (5) and 3-hydroxy-4-methyl-2(5H)-thiophenone (6). By carrying out the reaction in 18O-enriched H2O, the intramolecular nature of the cephalexin degradation has been demonstrated.

Keywords

Cephalexin, Mice, Inbred ICR, Magnetic Resonance Spectroscopy, Chemical Phenomena, Hydrolysis, Cephalosporins, Chemistry, Mice, Animals, Female

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	33
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%