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Poly(oligonucleotide)

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 31 Jul 2014 English Publisher:American Chemical Society (ACS)Journal:Journal of the American Chemical Society, volume 136, pages 11,216-11,219 (issn: 0002-7863, eissn: 1520-5126,

Authors: James, Carrie R.; Rush, Anthony M.; Insley, Thomas; Vuković, Lela; Adamiak, Lisa; Král, Petr; Gianneschi, Nathan C.;

doi: 10.1021/ja503142s

pmid: 25077676

pmc: PMC4140503

Poly(oligonucleotide)

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Abstract

Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.

Related Organizations

University of California, San Diego
United States
University of Illinois at Urbana Champaign
United States

Keywords

Peptide Nucleic Acids, Magnetic Resonance Spectroscopy, Polymers, Oligonucleotides, DNA, Single-Stranded, Nanoparticles, DNA, Polymerization

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Funded by

NSF| XSEDE: eXtreme Science and Engineering Discovery Environment