The Effect of Receptor Clustering on Vesicle−Vesicle Adhesion
Copyright policy )The Effect of Receptor Clustering on Vesicle−Vesicle Adhesion
As part of our studies into how the localization of cell adhesion molecules into lipid rafts may affect cell adhesion, we developed Cu(1), a synthetic copper(iminodiacetate)-capped receptor able to phase separate from fluid phospholipid bilayers. The extent to which Cu(1) clustered into adhesive patches on the surface of vesicles could be controlled by changing vesicle composition. Extensive receptor phase separation significantly enhanced vesicle-vesicle adhesion; only vesicles with adhesive patches (blue fluorescence) adhered to their conjugate histidine-coated vesicles (red fluorescence) to form large vesicle aggregates (shown).
- University of Salford United Kingdom
Receptors Role: BSU (Biological study, Cell adhesion molecules, Organelle (coated vesicle, Adhesion (cell adhesion, effect of receptor clustering on vesicle-vesicle adhesion), Receptors, Cell Surface, histidine-coated, unclassified), Phospholipids Role: BSU (Biological study, Receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (effect of receptor clustering on vesicle-vesicle adhesion), BIOL (Biological study) (effect of receptor clustering on vesicle-vesicle adhesion), Microscopy, Fluorescence, Molecular association (vesicle-vesicle, Cell Adhesion, Phospholipids Role: BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (effect of receptor clustering on vesicle-vesicle adhesion), Phase separation (effect of receptor clustering on vesicle-vesicle adhesion), PRP (Properties), Membrane (bilayer, receptor vesicle adhesion phospholipid bilayer, Organelle (coated vesicle, histidine-coated
Receptors Role: BSU (Biological study, Cell adhesion molecules, Organelle (coated vesicle, Adhesion (cell adhesion, effect of receptor clustering on vesicle-vesicle adhesion), Receptors, Cell Surface, histidine-coated, unclassified), Phospholipids Role: BSU (Biological study, Receptors Role: BSU (Biological study, unclassified), BIOL (Biological study) (effect of receptor clustering on vesicle-vesicle adhesion), BIOL (Biological study) (effect of receptor clustering on vesicle-vesicle adhesion), Microscopy, Fluorescence, Molecular association (vesicle-vesicle, Cell Adhesion, Phospholipids Role: BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (effect of receptor clustering on vesicle-vesicle adhesion), Phase separation (effect of receptor clustering on vesicle-vesicle adhesion), PRP (Properties), Membrane (bilayer, receptor vesicle adhesion phospholipid bilayer, Organelle (coated vesicle, histidine-coated
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