Covalent Display of Oligosaccharide Arrays in Microtiter Plates
Copyright policy )Covalent Display of Oligosaccharide Arrays in Microtiter Plates
A covalent array for the display of complex oligosaccharides in microtiter plates has been developed. This strategy is conducive to the display of carbohydrates to proteins of interest such as lectins and antibodies, including the broadly neutralizing antibody 2G12 against HIV envelope oligomannose and can be cleaved from the surface for further characterization by mass spectrometry. The system was used to probe the multivalent interaction of 2G12 with an optimal epitope (Kd 0.1 muM).
- Scripps Research Institute United States
Dithiothreitol, Spectrometry, Mass, Electrospray Ionization, Carbohydrate Sequence, Molecular Structure, Molecular Sequence Data, Combinatorial Chemistry Techniques, Oligosaccharides, Triazoles
Dithiothreitol, Spectrometry, Mass, Electrospray Ionization, Carbohydrate Sequence, Molecular Structure, Molecular Sequence Data, Combinatorial Chemistry Techniques, Oligosaccharides, Triazoles
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