A PNA4 Quadruplex
Copyright policy )A PNA4 Quadruplex
A tetrameric PNA, TGGG, has been shown to form an intermolecular G-quadruplex. Nanoelectrospray mass spectrometry, combined with solution-phase H/D exchange, established formation of a specific tetramolecular complex. UV melting studies show that this complex undergoes a quadruplex melting transition. This is a novel four-stranded structure that offers the gross structural features of a DNA quadruplex, but without the negatively charged backbone.
- University of Cambridge United Kingdom
- International University in Moscow Russian Federation
Peptide Nucleic Acids, Spectrometry, Mass, Electrospray Ionization, Freeze Drying, Chemical Phenomena, Chemistry, Physical, Ultraviolet Rays, Circular Dichroism, Molecular Conformation, Hydrogen Bonding, Indicators and Reagents, Deuterium Oxide
Peptide Nucleic Acids, Spectrometry, Mass, Electrospray Ionization, Freeze Drying, Chemical Phenomena, Chemistry, Physical, Ultraviolet Rays, Circular Dichroism, Molecular Conformation, Hydrogen Bonding, Indicators and Reagents, Deuterium Oxide
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