Reactions of diosgenin a sterol isolated from an extract of Dioscorea tokoro are discussed. Diosgenin is known to possess a 56 double bond and 1 nuclear hydroxyl group in the 3-position with the beta configuration appearing as in cholesterol. The compound was subjected to reactions applied to sarsasapogenin and other steroidal sapogenins for the removal of the side chain. This resulted in derivatives of the pregnane and androstane series. Diosgenin can also be easily correlated with other sapogenins. The experimental procedures are described.