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ACS Chemical Biology
Article
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ACS Chemical Biology
Article . 2006 . Peer-reviewed
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ACS Chemical Biology
Article . 2007
Data sources: Europe PubMed Central
https://dx.doi.org/10.1021/cb6...
Article
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Chemical Modifications Rescue Off-Target Effects of RNAi

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2006 English Publisher:American Chemical Society (ACS)Journal:ACS Chemical Biology, volume 1, pages 274-276 (issn: 1554-8929, eissn: 1554-8937, Copyright policy )
Authors: Ola, Snøve; John J, Rossi;

doi: 10.1021/cb6002256

pmid: 17163754

Chemical Modifications Rescue Off-Target Effects of RNAi

Abstract

RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.

Related Organizations
Keywords

Gene Targeting, Animals, Humans, RNA Interference, RNA, Small Interfering

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 34
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
34
Top 10%
Top 10%
Top 10%
bronze