Synthesis of Symmetrical and Unsymmetrical PAMAM Dendrimers by Fusion between Azide- and Alkyne-Functionalized PAMAM Dendrons
Copyright policy )Synthesis of Symmetrical and Unsymmetrical PAMAM Dendrimers by Fusion between Azide- and Alkyne-Functionalized PAMAM Dendrons
A new convergent synthetic method for the synthesis of PAMAM dendrimers has been developed. The fusion between propargyl-functionalized PAMAM dendrons and azido-functionalized PAMAM dendrons via the Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction (click chemistry) of an alkyne and an azide leads to the formation of symmetric PAMAM dendrimers in high yields. Furthermore, the coupling reactions between the different generation dendrons afford the size-differentiated unsymmetrical PAMAM dendrimers.
- Dongguk University Korea (Republic of)
- Dong-A University Korea (Republic of)
- Pusan National University Korea (Republic of)
Azides, Dendrimers, Molecular Structure, Polymers, Surface Properties, Biocompatible Materials, Mass Spectrometry, Cyclization, Alkynes, Polyamines
Azides, Dendrimers, Molecular Structure, Polymers, Surface Properties, Biocompatible Materials, Mass Spectrometry, Cyclization, Alkynes, Polyamines
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