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Phototriggered Local Anesthesia

descriptionPublicationkeyboard_double_arrow_right Article 14 Dec 2015 China (People's Republic of) Publisher:American Chemical Society (ACS)Journal:Nano Letters, volume 16, pages 177-181 (issn: 1530-6984, eissn: 1530-6992,

Authors: Weiping Wang; Weiping Wang; James B. Mcalvin; Changyou Zhan; Changyou Zhan; Brian P. Timko; Brian P. Timko; +5 Authors

doi: 10.1021/acs.nanolett.5b03440

pmid: 26654461

handle: 10722/236726

Phototriggered Local Anesthesia

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Abstract

We report a phototriggerable formulation enabling in vivo repeated and on-demand anesthesia with minimal toxicity. Gold nanorods (GNRs) that can convert near-infrared (NIR) light into heat were attached to liposomes (Lip-GNRs), enabling light-triggered phase transition of their lipid bilayers with a consequent release of payload. Lip-GNRs containing the site 1 sodium channel blocker tetrodotoxin and the α2-adrenergic agonist dexmedetomidine (Lip-GNR-TD) were injected subcutaneously in the rat footpad. Irradiation with an 808 nm continuous wave NIR laser produced on-demand and repeated infiltration anesthesia in the rat footpad in proportion to the irradiance, with minimal toxicity. The ability to achieve on-demand and repeated local anesthesia could be very beneficial in the management of pain.

Country

China (People's Republic of)

Related Organizations

Massachusetts Institute of Technology
United States
Harvard University
United States
Boston Children's Hospital
United States
University of Hong Kong (香港大學)
China (People's Republic of)
Koch Institute for Integrative Cancer Research At MIT
United States

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Keywords

Nanotubes, Light, Phototriggering, Tetrodotoxin, Rats, Drug Delivery Systems, gold nanorod, liposome, Liposomes, Animals, Humans, Gold, local anesthesia, Dexmedetomidine, tetrodotoxin, Anesthesia, Local

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	85
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%