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Resistance and tolerance mechanisms to antifungal drugs in fungal pathogens

Name: Resistance and tolerance mechanisms to antifungal drugs in fungal pathogens
Creator: Dominique Sanglard
Keywords: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2003 English Publisher:Elsevier BVJournal:Mycologist, volume 17, pages 74-78 (issn: 0269-915X, eissn: 1474-0605,

Authors: Dominique Sanglard;

doi: 10.1017/s0269915x03002076

Resistance and tolerance mechanisms to antifungal drugs in fungal pathogens

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Abstract

Fungal pathogens are using several mechanisms to circumvent the inhibitory actions of antifungal drugs. The variety of these mechanisms was revealed in recent years by several laboratories with molecular approaches. Besides the identification of genes involved in antifungal drug resistance and the discovery of alternative pathways of resistance (i.e. biofilm formation), novel concepts in the understanding of the survival of fungal pathogen in the presence of antifungal drug (antifungal tolerance) have emerged.

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