Abstract We construct two families of orthogonal polynomials associated with the universal central extensions of the superelliptic Lie algebras. These polynomials satisfy certain fourth-order linear differential equations, and one of the families is a particular collection of associated ultraspherical polynomials. We show that the generating functions of the polynomials satisfy fourth-order linear PDEs. Since these generating functions can be represented by superelliptic integrals, we have examples of linear PDEs of fourth order with explicit solutions without complete integrability.